基于数据挖掘技术探讨治疗萎缩性胃炎方剂组方规律分析

Analysis of Laws of Compositions and Medications for Treating Chronic Atrophic Gastritis Based on Data Mining Technology

目的分析中国期刊全文数据库(CNKI)中以中医药治疗萎缩性胃炎的组方用药规律,为进一步探究中医药治疗萎缩性胃炎及新药研发提供参考。方法检索筛选CNKI中运用中医药处方治疗萎缩性胃炎的文献,构建中医药治疗萎缩性胃炎的数据库,采用中医传承辅助平台软件(V2.5)集成的数据挖掘方法,分析近30余年治疗萎缩性胃炎的方剂组方规律。结果共筛选治疗萎缩性胃炎文献389篇,处方280个,中药223味,处方中药物出现频次前10位依次为白芍、白术、甘草、党参、茯苓、丹参、半夏、黄连、炙甘草、黄芪。常用药对前10位依次为白术—茯苓、白术—白芍、党参—白术、甘草—白芍、丹参—白术、白术—甘草、丹参—白芍、炙甘草—白芍、白芍—柴胡、半夏—黄连,演化得到核心组合32个,新处方16个。结论目前治疗萎缩性胃炎的药物以健脾益气、和胃降逆、化瘀解毒为主,且药性平和,并无峻猛攻邪之品。

Objective To analyze laws of compositions and medications for treating atrophic gastritis（ CAG） in China National Knowledge Infrastructure（ CNKI）,thus providing reference for further research TCM on CAG and RD of new traditional Chinese medicines. Methods Literatures of TCM prescriptions for treating CAG used in CNKI were electronically retrieved to construct database on Chinese medicines treating CAG. Using data mining technology integrated by TCM Inheritance Support System（ Version 2. 5）,laws of compositions and medications for treating CAG in recent more than 30 years were analyzed. Results A total of 389 literatures on treating CAG were screened,including 280 prescriptions and 223 Chinese herbs/drugs. The top 10 Chinese herbs/drugs in the prescriptions were sequenced by occurrence frequency as follows：white peony root,Atractylodes macrocephala Koidz,licorice,Codonopsis pilosula,poria,Salvia Miltiorrhiza,Ternate Pinellia,Coptis chinensis,Radix Glycyrrhizae preparata,Astragalus membranaceus. The top 10 couplet medicines were as follows： Atractylodes macrocephala Koidz-poria,Atractylodes macrocephala Koidz—white peony root,Codonopsis pilosula —Atractylodes macrocephala Koidz,licorice—white peony root,Salvia Miltiorrhiza —Atractylodes macrocephala Koidz,Atractylodes macrocephala Koidz—licorice,Salvia Miltiorrhiza —white peony root,Radix Glycyrrhizae preparata—white peony root,white peony root—Radix Bupleuri,Ternate Pinellia —Coptis chinensis. There were 32 core combinations and 16 new recipes. Conclusions Chinese herbs/drugs used for CAG mainly had actions of invigorating Pi and benefiting qi,harmonizing Wei for descending adverse qi,removing stasis and detoxification. They were all neutral in nature.