重组人脑钠肽治疗老年急性失代偿期心力衰竭患者的疗效

Therapeutic effect of recombinant human brain natriuretic peptide on aged patients with acute decompensated heart failure

目的:探讨冻干重组人脑利钠肽(rhBNP)对老年急性失代偿期心力衰竭(ADHF)患者的效果。方法:选择我院收治的98例老年ADHF患者作为研究对象,随机分为常规治疗组(50例)和rhBNP组(48例,在常规治疗组的基础上加用静脉注射rhBNP),治疗72h后,检测心功能各项指标和比较两组患者总有效率及药物不良反应。结果:与治疗前比较,两组治疗72h后左室射血分数(LVEF)明显提高,24h尿量明显增加(P均=0.001);且与常规治疗组比较,rhBNP组治疗后LVEF[(45.9±7.8)%比(57.4±7.9)%]明显提高,24h尿量[(1637.5±103.2)ml比(1836.4±118.4)ml]明显增加(P均=0.001)。治疗7d后,rhBNP组总有效率明显高于常规治疗组(93.75%比82.00%,P=0.033)。两组不良反应发生率差异无统计学意义(P=0.898)。结论:重组人脑利钠肽可显著改善老年急性失代偿期心力衰竭患者心功能,疗效显著。

Objective： To explore therapeutic effect of recombinant human brain natriuretic peptide （rhBNP） in aged patients with acute decompensated heart failure （ADHF） . Methods： A total of 98 aged ADHF patients treated in our hospital were selected and randomly divided into routine treatment group （n = 50） and rhBNP group （n = 48, received intravenous injection of rhBNP based on routine treatment group）. After 72h treatment, cardiac function indexes, total effective rate and incidence of adverse drug reactions （ADR） were measured and compared between two groups. Results： Compared with before treatment, after 72h treatment, there were significant rise in left ventricular ejection fraction （LVEF） and 24h urine volume in both groups （P = 0. 001 aid ; compared with routine treatment group after treatment, there were significant rise in LVEF [（45.9 ± 7.8）% vs. （57. 4 ± 7.9）%1 and 24h urine volume [- （1637.5±103.2） ml vs. （1836.4±118. 4） ml], P = 0. 001 all. On 7d after treatment, total effective rate of rhBNP group was significantly higher than that of routine treatment group （93. 75% vs. 82.00%, P = 0. 033）. There was no significant difference in incidence rate of ADR between two groups, P = 0. 898. Conclusion.. Recombi- nant human brain natriuretic peptide can significantly improve heart function, and the therapeutic effect is significant in aged patients with acute decompensated heart failure.