新疆维吾尔自治区乌鲁木齐市维吾尔族和汉族育龄期妇女碘营养状况调查分析

Investigation and analysis of iodine nutritional status in Han and Uygur nationalities in childbearing age women in Urumqi,Xinjiang Uygur Autonomous Region

目的了解新疆维吾尔自治区乌鲁木齐市某社区维吾尔族和汉族育龄期妇女碘营养水平及其差异。方法选取2013年5月在乌鲁木齐某社区进行甲状腺疾病流行病学调查的2 080例受试者中,资料完整的585例女性受试者为研究对象,年龄为18~45岁。按照不同民族,将其分为维吾尔族组(n=326)与汉族组(n=259)。回顾性分析2组受试者人体质量指数(BMI)、颈围、腹围、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)水平等一般临床资料,采用尿中碘的砷铈催化分光光度法检测尿碘水平。本研究遵循的程序符合新疆维吾尔自治区人民医院伦理委员会制定的伦理学标准,得到该委员会批准,并与受试者签署临床研究知情同意书。结果(1)维吾尔族组受试者BMI和腹围,均大于汉族组受试者,2组比较,差异均有统计学意义(t=7.015、7.104,P<0.001)。维吾尔族组和汉族组受试者的年龄、颈围及TSH、TgAb和TPOAb水平比较,差异均无统计学意义(P>0.05)。(2)维吾尔族组、汉族组受试者尿碘水平中位数分别为133.8μg/L(34.1~568.2μg/L)和131.7μg/L(27.7~513.6μg/L),二者比较,差异无统计学意义(Z=-0.156,P=0.876)。维吾尔族组、汉族组受试者碘缺乏、碘适量、碘超足量及碘过量构成比比较,差异无统计学意义(χ~2=1.556,P=0.669)。结论新疆维吾尔自治区乌鲁木齐市某社区维吾尔族、汉族育龄期部分妇女存在碘缺乏,维吾尔族和汉族育龄期妇女碘营养状况无明显差异。

Objective To investigate the urinary iodine levels and differences between Han and Uygur nationalities in childbearing age women in Urumqi,Xinjiang Uygur Autonomous Region.Methods In May 2013,a total of 585 subjects who received epidemiological survey of thyroid disorders with complete clinical data in a community of Urumqi were chosen as research subjects.According to different nationalities,they were divided into Uygur group（n=326）and Han group（n=259）.Body mass index（BMI）,neck circumference,waist circumference,thyroid-stimulating hormone（TSH）,thyroglobulin antibody（TgAb）,and thyroid peroxidase antibody（TPOAb）levels were retrospectively analyzed.The levels of urinary iodine were determined by As^（3＋）-Ce^（4＋）catalytic spectrophotometry.This study has been approved by the ethic committee board of People′s Hospital of Xinjiang Uygur Autonomous Region.Results（1）BMI and waist circumference in Uygur group were higher than those of Han group,and the differences were statistically significant（t=7.015,7.104;P〈0.001）.However,there were no significant differences between two groups in the aspects of age,neck circumference,TSH,TgAb and TPOAb levels（P〈0.05）.（2）The median urinary iodine levels of Uygur group and Han group were 133.8 μg/L（34.1-568.2μg/L）and 131.7μg/L（27.7-513.6μg/L）,respectively,which showed no significant difference（Z=-0.156,P =0.876）.Furthermore,there was no statistical difference between Uygur group and Han group among iodine deficiency（32.8%vs 31.3%）,iodine sufficient（43.2%vs 45.2%）,iodine super-sufficient（12.6%vs 14.7%）,and iodine excess（11.4% vs 8.9%）（χ~2=1.556,P=0.669）.Conclusions Part of both Uygur and Han nationality women during their childbearing age in a community in Urumqi are suffering from iodine deficiency.And there is no statistically significant difference between them in iodine nutritional status.