细胞外基质在支气管肺发育不良发病机制中的作用

Roles of extracellular matrix in bronchopulmonary dysplasia:research progress

支气管肺发育不良(BPD)是发生于早产儿机械通气或氧疗后常见的慢性呼吸系统疾病。随着近年早产儿存活率的提高,BPD已成为新生儿重症监护病房的棘手问题之一。目前,BPD的发病机制尚未完全阐明,其可能与肺发育相关基因的协同表达、细胞通讯、物理作用力、细胞与细胞外基质(ECM)的相互作用受干扰有关。其中,ECM是存在于细胞间的动态网状结构,由纤维蛋白、糖蛋白复合物、ECM相关分子及ECM重构酶等构成,作为肺发挥正常功能的基础物质,十分重要。笔者拟就ECM在BPD发病机制中作用研究进展进行综述。

Bronchopulmonary dysplasia（BPD）is a kind of chronic lung diseases in premature infants after being treated with mechanical ventilation or oxygen therapy.With the development of neonatal survival rate,BPD has gradually become one of the most difficult problems in neonatal intensive care unit.Nowadays,the pathogenic mechanisms of BPD have not been well-elucidated.It may be associated with coordinated action of gene expression,cell-cell communication,physical forces,and cell interactions with the extracellular matrix（ECM）,which involved in the regulation of normal lung development together.ECM is the dynamic mesh structure existing between cells,which consist of the structural protein,dystrophin-glycoprotein,fibrin,extracellular matrix molecules and remodeling enzymes.ECM plays an important role as the basis material of lung function.In this review,we will focus on the recent research progresses about the role of ECM in the pathogenesis of BPD.