柠檬酸浓度对硼酸盐玻璃骨水泥性能的影响

Effect of Citric Acid Concentration on the Properties of Borate Glass Bone Cement

以壳聚糖-甘油磷酸钠-柠檬酸溶液为液相,制备了一种新型可注射的硼酸盐玻璃骨水泥,通过维卡仪、万能试验机、XRD、FTIR、SEM-EDS等探究了液相中柠檬酸浓度(0.1,0.2和0.4 g/m L)对硼酸盐玻璃骨水泥性能的影响。结果表明:柠檬酸浓度显著影响骨水泥的凝结时间和可注射性。柠檬酸浓度为0.2 g/m L时获得的骨水泥的凝结时间最短,为(16±0.5)min;可注射性最好,接近100%。骨水泥压缩强度随柠檬酸浓度增大而增强,最大可达(26.7±1.9)MPa。SEM照片显示骨水泥中生成了许多纳米微粒。XRD、FTIR和EDS等结果证明,这些纳米微粒主要是硼酸盐、磷酸盐和柠檬酸盐等物质,而且柠檬酸浓度能够影响骨水泥中硼酸盐晶体的形成。此外,柠檬酸能够加速玻璃颗粒在磷酸钠盐缓冲液中的降解速率。

Abstract： A novel injectable borate glass bone cement （BGBC） was prepared by using citric acid-IIglycerophos- phate-chitosan solution as setting solution. The effect of citric acid （H3Cit） concentration （0.1, 0.2 and 0.4 g/mL） on the properties of BGBC was investigated by using vicat apparatus, universal testing machine, XRD, FTIR, and SEM-EDS measurements. The experimental results indicate that H3Cit concentration significantly influences setting time and in- j ectability of BGBC. At the H3Cit concentration of 0.2 g/mL, BGBC obtains the shortest setting time of （164-0.5） min and best injectability, which is almost fully injectable. It compressive strength increases with the increase of H3Cit concentration, with the maximum compressive strength up to （26.74-1.9） MPa. SEM images show that a large amount of nanoparticles are formed in the BGBC. XRD, FTIR and EDS results confirm that these nanoparticles contain bo- rates, phosphates and phosphates. Furthermore, formation of borate crystals in the BGBC is influenced by H3Cit con- centration. Immersion experiment of borate glass particles into phosphate buffer with different H3Cit concentrations shows that the degradation of borate glass is accelerated by H3Cit.