聚多巴胺修饰的介孔二氧化硅微球的合成及其用于负载左旋薄荷醇凉味剂

Synthesis of Polydopamine Modified Mesoporous Silica Microspheres for Encapsulation of L-menthol

介孔二氧化硅材料具有巨大的孔隙率、开放的孔道结构、易于改性的孔道表面以及良好的生物相容性,广泛用于药物传递、吸附分离以及催化等领域。本研究通过非极性溶剂辅助共组装法合成了具有较大孔径(6.9 nm)和比表面积(615 m2/g)的介孔二氧化硅微球。采用纳米浇铸的方法,成功地将左旋–薄荷醇负载到该材料的孔内。进一步通过界面聚合的方法,在所得微球的表面涂覆一层聚多巴胺(PDA)涂层,从而将薄荷醇封装在微球的孔道内。利用PDA作为半透膜,研究了复合微球在不同温度的空气吹扫下释放薄荷醇的行为,发现在相对适宜的温度下PDA涂层有利于薄荷醇的可控缓慢释放。这些研究结果表明基于聚多巴胺修饰的介孔二氧化硅材料有望用于开发食品和医药等领域的缓释制剂。

Ordered mesoporous silica materials （OMS） possess high specific surface areas, large pore volume, open channel structure, easily tunable surface functionalities, and good biocompatibility. They have great potential for ap- plication in various fields, such as drug delivery, enzyme immobilization, and catalysis. In this study, ordered meso- porous silica microspheres with large pore sizes were synthesized via a non-polar solvent assisted co-assembly method in a water- n-hexane biliquid solution. The obtained mesoporous silica microspheres possess large pore size of 6.9 nm and high surface area of 615 m2/g. Through a nanocasting method, L-menthol was successfully loaded into the mesopores. Through an interface polymerization of dopamine, polydopamine （PDA） was deposited on the external surface of the composite microspheres. By monitoring the weight change of the composite microspheres during treat- ment by hot air flow, the menthol release behavior was evaluated. As a result of the presence of permeable PDA in shell, the composite microspheres were found to release L-menthol in a controllable way, especially at an appropriate temperature of about 50. This study provides an important primary guideline for potential applications of mesopor- ous silica functionalized with PDA in bio-medicine, adsorption and separation, and so on.