2[1]Vionnet N, Stoffel M, Takeda J, et al. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus[J]. Nature , 1992, 356:721-722.
3[2]Van Schaftingen E. A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1 -phosphate[J].Eur J Bichem, 1989, 179: 179-184.
4[3]Slosberg ED, Desai UJ, Fanelli B, et al. Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein[J]. Di abetes, 2001, 50(8): 1813-1820.
5[4]Clark DG, Filsell OH, Topping DL, et al. Effects of fructose concentration on carbohydrate metabolism, heat production and substrate cycling in isolated rat hepatocytes[J].Biochem J, 1979, 184: 501-507.
6[5]Elvira Alvarez, Isabel Roncero, Julie A Chowen, et al. Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brai n[J].J Neurochemistry, 2002, 80(1): 45-53.
7[6]Bennett WS, Steitz TA. Glucose-induced conformational change in yeast hexokinase[J].Proc Natl Acad Sci USA, 1978, 75: 4848-4852.
8[7]Charles RST, Harrison RW, Bell GI. Molecular model of human β-cell glucokinase built by analogy to the crystal structure of yeast hexkinase B[J].Diabet es, 1994, 43: 784-791.
9[8]Van Schaftingen E, Vegia-da-Cunha M, Niculescu L, et al. The regulatory protein of glucokinase[J].Bio Soc Trans, 1997, 25(1): 136-140.
10[9]Maria Veiga-da-Cunha, Van Schaftingen E. Identification of fructose 6-Phosphate- and fructose 1-Phosphate-binding residues in the regulatory protein of g lucokinase[J].J Biol Chem, 2002, 277(10): 8466-8473.
