阻塞性睡眠呼吸暂停低通气综合征和动脉硬化的相关性研究

Correlation between obstructive sleep apnea-hypopnea syndrome and Arteriosclerosis

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea and hypopnea syndrome,OSAHS)和动脉硬化之间的相关性。方法:选取2013年6月至2015年9月来我院体检科同时进行了多导睡眠检测图(Polysomnography,PSG)和动脉硬化检查的97例人员,其中经脉搏传导速度(ba PWV)、踝臂指数(ABI)和眼底镜检查确定为动脉硬化指标增高的53例为病例组,44例动脉硬化指标正常者为对照组,对比两组间动脉硬化相关危险因素,通过调整相关危险因素多因素回归分析后,获得OSAHS与动脉硬化相关性。结果:经组间比较分析,OSAHS、年龄、腰围、高血压、脂肪肝和空腹血糖损害等与动脉硬化相关,多因素逻辑回归分析后,仅年龄、高血压为动脉硬化的影响因素。结论:OSAHS非动脉硬化的独立影响因素,高血压和年龄可能增加动脉硬化发生率。

Objective： To analyze the correlation between obstructive sleep apnea-hypopnea syndrome（OSAHS） and Arteriosclerosis. Methods： 97 persons receiving physical examination who were conducted by Polysomnography（PSG） monitoring,all tested by pulse wave velocity（PWV） 、ankle-brachialindex（ABI） and funduscopic examination,53 identified by increased arterial stiffness index as a group,44 normal person as the control group,contrasted the associated risk factors of atherosclerosis between two groups,by adjusting the related risk factors after multiple factors regression analysis,obtained correlation between OSAHS and arteriosclerosis. Results： After compared between two groups,OSAHS,age,waist circumference,Impaired Fasting Glucose,high blood pressure,fatty liver associated with atherosclerosis,after multiple logistic regression analysis,only the age and high blood pressure relate with atherosclerosis. Conclusion： This study shows that OSAHS is not the independent influence factors of the atherosclerosis,high blood pressure and age could increase the risk of atherosclerosis.