摘要
目的探讨肺结核患者应用抗结核药物所致药物性肝损害的临床特点并分析相关危险因素,为临床预防和治疗抗结核药物性肝损害提供一定依据。方法选择2013年1月至2016年6月期间我院收治的563例肺结核患者为研究对象,对其中65例药物性肝损害患者的潜在危险因素进行统计学分析。结果抗结核药物所致肝损害的发生率为11.5%(65/563)。其中,男性与女性患者肝损害发生率,差异无统计学意义(P>0.05);老年与中青年患者肝损害发生率,差异有统计学意义(P<0.05)。另外,HBs Ag阳性患者、复发患者、过量饮酒患者、治疗3个月内肝损害发生率均明显升高(P均<0.05)。而吸烟、营养不良患者的肝损害发生率分别与不吸烟、营养正常患者相比差异无统计学意义(P>0.05)。结论肺结核患者药物性肝损害发病率与老年、HBs Ag阳性、复发、过量饮酒等危险因素密切相关,应密切关注具有相关危险因素人群的肝功情况,及早发现、预防和治疗,采取适当措施以避免或减少肝损害的发生。
Objective To investigate the clinical characteristics of tuberculosis patients with anti-tuberculosis drug-in- duced liver damage (ATLD) and analyze the related risk factors, to provide a certain basis for clinical prevention and treatment of ATLD. Methods 563 tuberculosis patients in our hospital between January 2013 and June 2016 were selected as research object, clinical data of patients were collected. Potential risk factors of patients with anti-tuberculosis drug-induced liver damage were analyzed by using statistical method. Results The incidence of ATLD was 11.5% (65/563). The incidence of ATLD in male patients had no significant difference compared to female patients (P〉0.05). The incidence of ATLD in senile patients was higher than non-senile patients (P〈0.05). In addition, the incidence of ATLD in patients with HBsAg, retreatment, intemperance or treatment within 3 months significantly increased (P〈 0.05). However, the incidence of ATLD in patients with smoking or malnutrition had no difference compared to non" smoking or normotrophic patients separately (P〉0.05). Conclusions Oldness, HBsAg positive, retreatment, intemperance and treatment within 3 months were closely related with the incidence of ATLD. Liver function of population with the potential high risk factors should be closely watched in order to early detection, prevention, treatment, and help to avoid or reduce the incidence of ATLD.
出处
《河南预防医学杂志》
2017年第9期683-685,721,共4页
Henan Journal of Preventive Medicine
关键词
肺结核
药物性肝损害
危险因素
预防
Tuberculosis
Drug-induced liver damage
Risk factor
Prevention