摘要
目的采用Meta分析的方法探讨牙周病与前列腺癌的相关性。方法计算机检索PubMed、Embase、中国知网和万方数据库中自建库至2016年12月28日之间公开发表的相关文献,对符合纳入标准的研究进行数据提取和质量评价后,采用RevMan 5.3软件进行Meta分析。结果最终纳入4项队列研究,质量均较高。基于校正的Meta分析结果显示,牙周病能增加前列腺癌的发病风险1.10倍,但无统计学意义[HR=1.10,95%CI(0.86~1.40)]。敏感性分析显示结果稳健性好。结论当前证据表明牙周病没有显著增加前列腺癌的发病风险。
Objective To explore the association between periodontal disease and prostate cancer using a Meta-analytic approach. Methods The PubMed,Embase,CNKI and Wanfang Database were searched for relevant studies published up to Dec. 28,2016. After data extraction and quality assessment for included studies, a Meta-analysis was conducted using the Rev- Man 5.3 software. Results A total of 4 cohort studies were included,all with high quality. The results of adjusted data showed that periodontal disease increased the risk of prostate cancer incidence 1.10 times, but the association was no significant [-HR = 1.10,95 % CI （0.86--1.40）]. Sensitivity analysis showed the result was robust. Conclusion Based on current evidence, perio- dontal disease dose not significantly increase the risk of prostate cancer.
作者
訾豪
王朝阳
陈少华
郑忠立
李柄辉
曾宪涛
李晓东
ZI Hao WANG Chao-yang CHEN Shao-hua ZHENG Zhong-li LI Bing-hui ZENG Xian-tao LI Xiao-dong(Department of Urology, Huaihe Hospital of Henan University,Kaifeng 475000 Center for Evidence- Based Medicine, Huaihe Hospital of Henan University,Kaifeng 475000 Center for Evidence-Based Medi- cine, Henan University, Kaifeng 475000 Center for Evidence-Based and Translation Medicine, Zhongnan Hospital of Wuhan University~ Center for Evidence-Based and Translation Medicine,Wuhan University, De- partment of Evidence-Based Medicine and Clinical Epidemiology, the Second Clinical College of Wuhan Uni- versity, Wuhan 430071, China)
出处
《现代泌尿外科杂志》
CAS
2017年第8期613-617,共5页
Journal of Modern Urology
关键词
牙周病
牙周炎
前列腺癌
危险因素
队列研究
META分析
periodontal disease
periodontitis
prostate cancer
risk factor
cohort studies
Meta-analysis
