我国6城市2010～2015年神经保护剂用药情况分析

Analysis of the medication situation of neuroprotective agents from 2010 to 2015 in 6 cities of our country

目的研究分析我国6城市(北京、天津、上海、广州、杭州、成都)2010~2015年神经保护剂用药情况现状及趋势,为促进药物的合理使用、合理配置医疗资源提供基础参考数据。方法利用"医院处方分析合作项目"收集数据,并计算日均费用(DDDc)、药物利用指数(DUI)、序号比(B/A值)和联合用药等情况。结果各地区DDDc排名靠前品种基本相似,且都为常用品种,依次为脑苷肌肽、依达拉奉、神经节苷脂、法舒地尔和鼠神经生长因子,这5种药物日花费金额高,患者经济负担重。DUI>1.0的药品有3种,分别是神经节苷脂、鼠神经生长因子和小牛血清去蛋白,存在药品滥用、过度使用的情况,为不合理用药。神经保护剂应用以单一用药方式为主,二联用药从2010年的5.29%上升到2015年的14.89%。结论各地均存在药品过度应用情况,合理使用神经保护剂应得到更多重视。

Objective To study the neuroprotective agents utilization in 6 cities （Beijing, Tianjin, Shanghai, Guangzhou, Hangzhou, Chengdu） of China from 2010 to 2015, in order to provide basis for promoting the rational use of drugs and medical resources. Methods ＂Hospital prescription analysis cooperation project＂ was used for data collection. The av- erage daily cost value （DDDe）, drug utilization index （DUI）, serial number ratio （B/A value） and medication combination were calculated. Results The drugs that ranked in the front of DDDc were basically similar kinds in different regions. Those drugs were all general types, including Brain Nucleoside Caruosine, Edaravone, Ganglioside, Fasudil and Mouse Nerve Growth Factor. These drugs were frequently used with high cost and heavy economic burden. There were 3 kinds of drugs with the DUI 〉 1.0, which were Gangliosides, Mouse Nerve Growth Factor and Deproteinized Calf blood Serum. These drugs were excessive use in clinic and they were not rational used. The neuroproteetive agents were most given by the single way, the double combination therapy had increased from 5.29% in 2010 to 14.89% in 2015. Con- clusion There are excessive use of neuroprotective agents in these regions. The rational use of neuroprotective agents is deserved more attention.