糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期的疗效观察

Clinical effect of glucocorticoid and terbutaline in the treatment of acute exacerbation of COPD

目的观察慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期患者以特布他林、糖皮质激素药物配合治疗的效果。方法选取我院于2014年3月~2016年7月期间收治的106例慢阻肺急性加重期患者,采用随机数字表法分为对照组和观察组,其中对照组52例(布地奈德)、观察组54例(加用特布他林),评估用药后慢阻肺治疗效果,比较治疗前后两组肺功能指标(FVE1、PEF)变化情况。结果观察组治疗率为92.6%优于对照组的82.7%,观察组治疗效果理想、患者恢复好(P<0.05);肺功能指标FVE1、PEF入院时两组比较无明显差异(P>0.05),用药后患者均有明显改善,观察组肺功能指标改善效果优于对照组(P<0.05)。结论急性加重期慢阻性肺患者,以特布他林、糖皮质激素药物配合治疗,患者治疗效果理想,症状明显改善且肺功能明显恢复。

Objective To observe the clinical effect of terbutaline and glucocorticoid in the treatment of acute exacer- bation of COPD（chronic obstructive pulmonary disease）. Methods 106 patients with acute exacerbation of COPD treated from March 2014 to July 2016 in our hospital were selected and randomly divided into control group（52 cases） and ob- servation group （54 cases）. The control group was given budesonide; the observation group was given terbutaline. The clinical effect and pulmonary function index of FVE1 and PEF was compared between the two groups. Results The clinical effective rate in observation group （92.6%） was higher than that in the control group（82.7%） （P〈0.05）; there was no significantly difference upon admission to hospital,the pulmonary function index of FVE1 and PEF between the two groups（P〉0.05）; after treatment, the pulmonary function index in observation group was better than that in the control group（P〈0.05）. Conclusion The combined therapy of terbutaline and glucocorticoid has an obvious effect in patients with acute exacerbation of COPD, can imorove the clinical svmotoms and oulmonarv function index.