麝香保心丸对冠心病心绞痛患者Ghrelin/obestatin比值的影响

Effect of Shexiang Baoxin pills on the ratio of Ghrelin/obestatin in coronary heart disease patients with coronary heart disease and angina pectoris

目的观察麝香保心丸对冠心病心绞痛患者Ghrelin/obestatin比值的影响及临床疗效。方法收集2012年1月~2016年6月诊治的冠心病心绞痛患者88例,随机分为观察组(n=44)和对照组(n=44),对照组采用辛伐他汀、硝酸异山梨酯片、阿司匹林常规西医治疗,观察组在对照组的基础上加用麝香保心丸治疗,两组治疗时间均为1个月。采用酶联免疫吸附试验检测Ghrelin、obestatin水平,并比较其治疗前后水平变化。结果观察组治疗总有效率高于对照组(77.3%vs 59.1%),差异具有统计学意义(P<0.05)。治疗后,观察组患者的心绞痛发作次数、持续时间及硝酸甘油用量均低于对照组患者[发作次数:(7.8±1.7)次/周vs(13.2±2.5)次/周;持续时间:(3.5±1.3)min/次vs(5.7±2.2)min/次;硝酸甘油用量:(2.1±0.6)mg vs(4.3±1.5)mg],差异均有统计学意义(P<0.01)。治疗后,观察组患者Ghrelin/obestatin比值明显高于对照组患者[(62.95±14.36)vs(45.21±10.28)],差异有统计学意义(P<0.05)。结论麝香保心丸治疗冠心病心绞痛疗效明显,对冠心病心绞痛的发作有一定的保护作用,能增加Ghrelin/obestatin比值。

Objective To observe the effect of Shexiang Baoxin pill on the ratio of Ghrelin/obestatin in patients with angina pectoris of coronary heart disease and its clinical curative effect. Methods A total of 88 patients with coronary heart disease and angina pectoris who were diagnosed from January 2012 to June 2016 were randomly divided into ob- servation group（n=44） and control group（n=44）, the control group was treated with simvastatin, isosorbide dinitrate tablets, aspirin and conventional western medicine. The observation group was treated with Shexiang Baoxin pills on the basis of the control group, and the treatment time was 1 month in the two groups. The levels of Ghrelin and obestatin were detected by enzyme-linked immunosorbent assay, and the changes were compared before and after treatment. Re- sults The total effective rate of the observation group was higher than that of the control group （77.3% vs 59.1%）, the difference was statistically significant （P〈O.05）. After treatment, the frequency of angina peetoris, the duration and the amount of nitroglycerin in the observation group were lower than those in the control group [Number of episodes： （7.8± 1.7） times/week vs （13.2±2.5） times/week; Duration time： （3.5±1.3） rain/time vs （5.7±2.2）rain/time; Nitroglycerin dosage： （2.1±0.6） mg vs （4.3±1.5） rag], the difference was statistically signifieant（P〈O.Ol）. After treatment, the ratio of Ghrelin/ obestatin in the observation group was significantly higher than that in the control group[（62.95±14.36） vs （45.21±10.28）], the difference was statistically significant（P〈O.05）. Conclusion Shexiang Baoxin pill is effective in the treatment of coronary heart disease and angina peetoris, it can protect the angina pectoris of coronary heart disease and increase the ratio of Ghrelin/obestatin.