非遗传因素与肝移植患者他克莫司维持剂量的相关性研究

Research on the Correlation between Non-genetic Factors with Maintenance Dose of Tacrolimus

目的:探讨肝移植患者接受他克莫司(FK 506)维持剂量的相关因素。方法:回顾性分析肝移植术后接受以FK 506为基础的免疫抑制方案、服药约4个月血药浓度维持在5~8μg·L^(-1)的50例患者的年龄、性别、体重、肝肾功能、血浆白蛋白水平等与FK 506维持剂量的相关性。结果:不同性别的患者FK 506维持剂量无统计学差异。FK 506维持剂量/浓度与患者谷丙转氨酶(r=-0.507,p<0.05)、谷草转氨酶(r=-0.505,p<0.05)水平负相关;与年龄、血肌酐、尿素氮、肌酐清除率及白蛋白等相关性弱。结论:临床应兼顾患者肝功能等,制定FK 506个体化给药方案。

Objective： To investigate the influence factors on the maintenance dose of tacrolimus in liver transplant patients. Methods： Fifty liver transplant patients treated with tacrolimus for four months with the concentration of tacrolimus between 5 and 8 μg·L-1 were enrolled in this study. Results： The maintenance doses of tacrolimus were not significantly different between sexes. The ratios of the maintenance dose to the concentration of tacrolimus were negatively correlated with the levels of alanine aminotransferase and aspertate aminotransferase, but had weak relationships with ages, creatinine, urea nitrogen, creatinine clearance rate and albumin. Conclusion： The liver function should be taken into consideration in order to achieve individualized tacrolimus dosing.