摘要
目的:探讨成人斯蒂尔病(AOSD)的中医证型分布与患者一般情况、服用糖皮质激素时间及C-反应蛋白(CRP)、血清铁蛋白(SF)的相关性。方法:回顾性纳入2011年1月至2015年12月住院确诊的AOSD患者108例,频数表描述证型分布,SPSS19.0统计分析各影响因素与证型相关性。结果:108例AOSD患者67.59%在春夏发病,出现频率大于50%的症状有发热、皮疹、咽痛、关节痛、肌痛、瘰疬肿痛、乏力,证型分布为气阴两虚兼湿热痹阻证(25.93%)、湿热痹阻证(21.30%)、阴虚内热证(17.59%)、气营两燔证(15.74%)、气阴两虚证(10.19%)、卫气同病证(9.26%);病程及服用激素时间长短、CRP、SF均影响证型分布。结论:AOSD多见中青年女性,典型症状为发热、皮疹、咽痛、关节痛,中医证型以虚实夹杂的复合证型气阴两虚兼湿热痹阻证最常见,卫气同病证最少见,病程、服用激素时间、CRP、SF与证型有明显相关性,即病程及服用激素时间越长表现为虚证越明显,CRP、SF越高病程越短则实证越明显。
Objective: Take a discussion about the correlation between TCM syndromes of AOSD and basic situation of patients,taking glucocorticoid time and CRP,SF. Methods: Retrospective inclusion is used on 108 AOSD in our hospital from January 2011 to December 2015,frequency table describe syndrome distribution,use SPSS19. 0 statistical software to analyze the correlation between various factors and syndrome. Results: In 108 AOSD patients,67. 59% in the spring and summer onset,symptoms appear more than 50% are fever,rash,sore throat,joint pain,myosalgia,scrofulous sore,weak; Distribution of syndrome: Qi-yin deficiency and Dampness-heat blockage( 25. 93%),Dampness-heat blockage type( 21. 30%),Yin deficiency inner Heat( 17. 59%),Qi Ying two burnt is( 15. 74%),Qi-Yin deficiency is( 10. 19%),Wind-heat invading( 9. 26%); Gender and age have no effects on the distribution of syndrome,course of disease,duration of hormone use、CRP、SF all the AOSD syndrome distribution. Conclusion: AOSD usually was found in young females,the course of disease is always long. The typical symptoms are fever,rash,sore throat,joint pain; the composite syndrome of deficiency and excess of Qi-yin deficiency and Dampness-heat blockage is the most common syndrome,Wind-heat invading is the least common; course of disease,taking glucocorticoid time,CRP,SF and syndrome are significantly correlated: the longer the course of disease,and the longer time of glucocorticoid used,deficiency symdrome is more obvious; If CRP,SF are more higher and course of disease is more shorter,then exterior syndrome is more obvious.
出处
《中国中医基础医学杂志》
CSCD
北大核心
2017年第7期963-966,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
中国中医科学院名医名家传承项目(CM2014GD1011)-胡荫奇学术思想与临床经验传承研究
关键词
成人斯蒂尔病
中医证型
相关性
Adult Onset Still's Disease
TCM syndrome
Correlation