硫辛酸注射液治疗甲基苯丙胺依赖者脑损伤的临床疗效观察

Clinical curative effect observation of thioctic acid injection in the treatment of brain damage caused by methamphetamine

目的观察硫辛酸注射液对甲基苯丙胺依赖者脑损伤的临床疗效。方法对2014年7月~2015年2月收治的男性甲基苯丙胺滥用者72例随机分成观察组和对照组各36例,两组均给予心理治疗及对症治疗,观察组患者实行硫辛酸注射液治疗,对照组患者采取注射用还原型谷胱甘肽治疗,21d为1个疗程,停药后比较两组治疗效果。结果治疗后,从戒断症状比较看,观察组总有效率为94.4%,对照组总有效率为75.0%,观察组总有效率高于对照组,差异有统计学意义(χ2=3.863,P=0.049)。治疗后,两组的Mo CA量表评分均比治疗前有改善,且观察组改善幅度优于对照组,差异均有统计学意义(P<0.05)。结论硫辛酸注射液治疗甲基苯丙胺依赖者脑损伤具有明显的临床疗效。

Objective To observe the clinical curative effect of Thioctic Acid Injection in the treatment of brain damage caused by methamphetaminc. Methods 72 cases of male methamphetamine abusers from July 2014 to February 2015 were randomly divided into observation group and control group with 36 cases in each. All the patients were given psychological treatment and symptomatic treatment. Patients in observation group were treated with Thioctic Acid Injection, and patients in control group were treated with Reduced Glutathione for Injection, 21d for 1 courses. After withdrawal, treatment effects of the two groups were compared. Results After treatment, compared with withdrawal symptoms, the total effective rate of the observation group was 94.4%, and that of the control group was 75%. The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant （X2=3.863, P=0.049 ）. After treatment, the MoCA scale scores of the two groups were better than those before treatment, and the improvement rate of the observation group was better than that of the control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion Thioctic Acid Injection has obvious clinical efficacy in the treatment of brain damage caused by methamphetamine.