阿立哌唑联用氨磺必利治疗男性精神分裂症患者高泌乳素血症30例

Aripiprazole Combined With Amisulpride in the Treatment of Male Schizophrenia Patients With Hyperprolactinemia in 30 Cases

目的观察阿立哌唑联用氨磺必利对男性精神分裂症高泌乳素血症患者临床疗效的影响。方法将60例精神分裂症高泌乳素血症患者随机分为氨磺必利组(对照组)和氨磺必利+阿立哌唑组(联合组)两个组,每组30例;于治疗前和治疗8周后检测患者血清泌乳素水平的变化,观察血清泌乳素水平变化情况。结果治疗8周后,两组总有效率差异无统计学意义(P>0.05);而治疗8周后联合组泌乳素水平低于对照组,两组差异有统计学意义(P<0.05)。结论阿立哌唑治疗男性精神分裂症患者疗效好且安全,而且氨磺必利联合阿立哌唑后明显降低男性精神分裂症高泌乳素血症患者血清泌乳素水平。

Objective To observe the effect of aripiprazole combined with amisulpride in the treatment of male schizophrenia patients with hyperprolactinemia. Methods 60 cases of schizophrenia patients with hyperprolactinemia were randomly divided into two groups, control group was treated with amisulpride（n=30）and the combined group with amisulpride and aripiprazole（n=30）. The prolaetin levels were detected and observed pre-treatment and 8 weeks post-treatment. Results After 8 weeks of treatment, there was no significant difference in the total effective rate between the two groups （P 〉 0.05）. After 8 weeks of treatment, prolactin levels in the combined group were lower than those in the control group, and the difference between the two groups was statistically significant （P 〈 0.05）. Conclusion Aripiprazole is a relatively effective and safe agent in the treatment with male hyperprolactinemia, and combined with amisulpride and aripiprazole decreased significantly for male schizophrenic patients with hyperprolactinemia serum prolactin level.