甲状腺过氧化物酶抗体检测对孕妇自身免疫性甲状腺功能紊乱的预测价值

Predictive Value of Thyroid Peroxidase Antibody Test in Autoimmune Thyroid Dysfunction in Pregnant Women

目的探讨甲状腺过氧化物酶抗体(TPOAb)检测对孕妇自身免疫性甲状腺功能紊乱的预测价值。方法选取我院2016年3月—2017年5月门诊或住院治疗的1 648例孕产妇;检测孕妇的血清TPOAb、促甲状腺激素(TSH)水平并进行对比。结果与正常组相比,紊乱组的TPOAb值、TSH值明显更高,差异具有统计学意义(P<0.05);与正常组相比,紊乱组的TPOAb阳性率明显更高,差异具有统计学意义(P<0.05)。结论孕妇自身免疫性甲状腺功能紊乱监测中,采用甲状腺过氧化物酶抗体检测方法,能够提高对疾病的预测价值。

Objective To investigate the predictive value of thyroid peroxidase antibody （TPOAb） in detecting autoimmune thyroid dysfunction in pregnant women. Methods From March 2016 to May 2017, 1 648 pregnant women in our hospital were enrolled in this study. The levels of serum TPOAb and thyroid stimulating hormone （TSH） in pregnant women were measured and compared, Results The values of TPOAb, TSH in the disorder group were higher than those in the normal group （P 〈 0.05）. Compared with the normal group, the positive rate of TPOAb in the disordered group was significantly higher, the difference was statistically significant （P 〈 0.05）. Conclusion Thyroid peroxidase antibody detection method can improve the predictive value of disease in the monitoring of autoimmune thyroid dysfunction in pregnant women.