静脉输液拔针时机对药理效应影响的探讨

Study on the Influence of Pharmacological Effections by Removing Needles at Different Time Points After Intravenous Infusion

目的探讨静脉输液完毕不同拔针时机对药理效应的影响及拔针的最佳时机。方法将60例静脉滴注头孢哌酮钠舒巴坦钠(以下简称头哌舒)的患者随机分成常规组和干预组,两组各30例。常规组按传统方法拔针;干预组待输液管内液面到莫菲氏滴管时将输液袋的针头拉下至接口处使袋内颈部药液滴净,然后等液面下降停止后逐渐调高输液架的高度,直到输液管伸展至垂直,再等液面停止下降时拔针,然后计算并比较两组的残余液量,分析血药浓度的降低对药理效应产生的影响。结果对常规组和干预组的残液量,损失头哌舒剂量,实际输入剂量达到的血清峰浓度进行统计学分析,两组差异有统计学意义(P<0.05)。结论对静脉输液患者实施拔针最佳时机干预,可保证高效的药物血清浓度,增强药理效应。

Objective To explore the impact of pharmacological effections by removing needles at different time points after intravenous infusion, and find which one was the best. Methods 60 patients with CPZ- SBP instillation were randomly assigned into the control group and the intervention group. There were 30 people in each group. Needles were removed by the eonventioanal way in the control group. As for the other group, in order to get the rest fluid drop to the Murphy＇s dropper, the needle tips of the infusion bags were drawn into the bag necks when the fluid lever declined to the Murphy＇s dropper. And then the infusion poles were lifted up after intravenous drip stopped so that it was nearly perpendicular to the floor. At last, needles were disconnected from the veins when the fluid stopped dripping again. The fluid loss of the two groups were measured and compared. The influence on pharmacological effect caused by lower drug blood cOncentration was analysed. Results There were datum being statistically analyzed including remaining solution, dose loss of CPZ-SBP and serum peak concentration based on actual transfusion volume of the control group and the intervention group. There was obvious difference between two groups （P 〈 0.05）. Conclusion Needle-disconnecting from intravenous infusion patients at the appropriate time could ganrantee the efficient plasma concentration and enhance the pharmcological effects.