探究FGFR4在卵巢子宫内膜异位囊肿中的表达情况及其与分期的关系

Investigation of the Expression of FGFR4 in Ovarian Endometrial Cysts and Its Relationship With Stage

目的探究成纤维细胞生长因子受体4(FGFR4)在卵巢子宫内膜异位囊肿中的表达情况及其与分期的关系。方法选取我院2014年1月—2015年9月收治的50例卵巢子宫内膜异位囊肿患者作为观察组,选取同时期因子宫肌瘤在我院手术的患者28例为作对照组,采用免疫组化方法检测FGFR4在异位内膜组、在位内膜组和正常内膜组中的表达情况以及在不同异位内膜分期中的表达情况。结果 FGFR4在异位内膜组、在位内膜组和对照组中的阳性表达率分别为88.00%、30.00%、39.29%;FGFR4会随着子宫内膜异位症分期增加而升高。结论FGFR4在卵巢子宫内膜异位囊肿中呈高表达,且与异位内膜分期呈正相关,表明FGFR4可能促进子宫内膜异位囊肿的发生发展。

Objective To investigate the expression of fibroblast growth factor receptor 4 （FGFR4） in ovarian endometrialcysts and its relationship with stage. Methods 50 cases of patients with ovarian endometrial cysts treated in our hospital from January 2014 to September 2015 were selected as the observation group, and 28 patients with hysteromyomas who were operated in our hospital in the same period were sel.ected as the control group. The expression of FGFR4 in ectopic endometrium group, eutopic endometrium group and normal control group was detected by immunohistochemistry, and the expression in different stages of ectopic endometrium was also analyzed. Results The positive expression rates of FGFR4 in ectopic endometrium group, eutopic endometrium group and normal control group were 88.00%, 30.00% and 39.29% respectively, and FGFR4 increased with the increase of endometriosis stage. Conclusion FGFR4 is highly expressed in ovarian endometrial cysts, and it is positively related to the stage of ectopic endometrium, suggesting that FGFR4 may promote the development of ovarian endometrial cysts.