功能性消化不良在慢性乙型病毒性肝炎患者中的发病研究

Study on Functional Dyspepsia in Patients With Chronic Hepatitis B

目的了解慢性乙型病毒性肝炎患者合并功能性消化不良(FD)的情况,并探讨其发病相关因素。方法选取2014年1月—2016年1月包钢医院门诊确诊的慢性乙型病毒性肝炎患者130例作为观察组;选取同期我院的健康志愿者70例作为对照组。根据罗马III的功能性消化不良诊断标准进行问卷调查,对符合FD标准的慢性乙型病毒性肝炎患者进行胃镜检查以除外器质性病变,并进行幽门螺旋杆菌检查、胃排空检查及抽血检测ALT、HBV-DNA指标。结果观察组患者发生FD的机率高于对照组,差异具有统计学意义(P<0.05)。通过多元相关分析显示慢性乙型病毒性肝炎患者FD的发生与患者血清ALT增高及胃排空延迟有关。结论慢性乙型病毒性肝炎患者易患FD,并与血清ALT水平及胃排空延迟有关。

Objective To assess prevalence of functional dyspepsia among chronic hepatitis B patients, and related factors are discussed. Methods A total of 130 patients with chronic hepatitis B diagnosed in outpatient department of Baotou Steel Hospital from January 2014 to January 2016 were selected as observation group. 70 healthy volunteers were selected as control group at the same period. A questionnaire survey was conducted according to the diagnostic criteria of functional dyspepsia in Rome III, gastroscopy should be performed on patients with chronic hepatitis B who are in line with the FD standard, in addition to organic lesions, and helicobacter pylori examination, gastric emptying examination and blood test, ALT, HBV-DNA indicators. Results The probability of observation group the incidence of FD in patients was higher than the control group, the difference was statistically significant （P〈0.05）. Multivariate correlation analysis showed that the incidence of FD in patients with chronic hepatitis B was related to the increase of serum ALT and the delay of gastric emptying. Conclusion Patients with chronic hepatitis B are susceptible to FD, which is related to serum ALT levels and delayed gastric emptying.