胃癌合并恶性腹腔积液采用腹腔热灌注化疗治疗的效果探讨

The Effect of Intraperitoneal Hyperthermic Perfusion Chemotherapy in the Treatment of Gastric Cancer With Malignant Ascites

目的观察胃癌合并恶性腹腔积液采用腹腔热灌注化疗治疗的效果。方法选取我院收治的90例胃癌合并恶性腹腔积液患者作为研究对象。依据随机分组原则,将全部患者分为对照组(经腹腔注入顺铂治疗)、观察组(采用腹腔热灌注化疗),每组各45例(两组患者均采用多西紫杉醇联合顺铂进行化疗),对比两组患者治疗效果及生活质量评分情况。结果观察组患者总有效率为97.78%,高于对照组(75.56%),差异具有统计学意义(P<0.05)。观察组患者生活质量评分均优于对照组,差异具有统计学意义(P<0.05)。结论对胃癌合并恶性腹腔积液采用腹腔热灌注化疗具有显著效果,且还能有效提高其生活质量。

Objective To observe the effect of intraperitoneal hyperthermic perfusion chemotherapy in gastric cancer with malignant peritoneal effusion. Methods 90 cases of patients with gastric cancer complicated with malignant peritoneal effusion were randomly divided into control group （treated by intraperitoneal injection of cisplatin）. The observation group （using intraperitoneal perfusion chemotherapy）, 45 cases in each group of patients were treated with docetaxel combined with cisplatin for chemotherapy）, compared with the two groups of patients with quality of life score. Results The total effective rate of the observation group was 97.78%, higher than that of the control group （75.56%）, the difference was statistically significant （P〈0.05）. The quality of life score of the observation group was better than that of the control group, the difference was statistically significant （P〈0.05）. Conclusion Intraperitoneal hyperthermic perfusion chemotherapy has a significant effect on gastric cancer with malignant peritoneal effusion, and it can also improve the quality of life.