右美托咪定对腹腔镜胆囊切除患者全麻中肝肾功能的保护作用研究

Protective Effect of Dexmedetomidine on Liver and Kidney Function during General Anesthesia in Patients with Laparoscopic Cholecystectomy

目的探察右美托咪定对腹腔镜胆囊切除患者全麻中肝肾功能的保护作用。方法选取择期予以腹腔镜胆囊切除患者70例为观察对象,随机法分成观察组与对照组,每组35例。观察组在全麻诱导前予以右美托咪定,对照组予以患者等量生理盐水。比较两组患者在不同时间点肝肾功能指标变化。结果两组主要肝肾功能指标包括:谷草转氨酶(AST)、谷丙转氨酶(ALT)、血尿素氮(BUN),两组各指标在T_0、T_1时点比较,均无差异,统计学分析无意义(P>0.05),在T_2、T_3时点,观察组各指标均明显低于对照组,具显著统计学差异(P<0.01)。结论右美托咪定对腹腔镜胆囊切除患者全麻中肝肾功能具有较好的保护作用,可在临床予以广泛推广及应用。

Objective To explore the protective effect of Dexmedetomidine on liver and kidney function during general anesthesia in patients with laparoscopic cholecystectomy. Methods 70 patients with selective laparoseopic cholecystectomy were selected as observation subjects and randomly divided into observation group and control group, 35 cases in each group. Observation group received Dexmedetomidine before general anesthesia induction and control group received same amount of normal saline. Liver and kidney function index changes at different points in time were compared between two groups of patients. Results The main liver and kidney function indexes included： aspertate aminotransferase （AST）, alanine aminotransferase （ALT） and blood urea nitrogen （BUN）, the indexes were not different at T0 and T1 points between two groups, and statistical analysis was not significant （P〉0.05）; at T2 and T3 points, all indexes of observation group were significantly lower than those of control group, and differences were statistically significant （P〈0.01）. Conclusion Dexmedetomidine has good protective effect on liver and kidney function during general anesthesia in patients with laparoscopic cholecystectomy, and should be clinically popularized and applied.