免疫细胞及细胞因子对肥胖哮喘的影响及机制

Influence and Mechanism of Immunocytes and Cytokines on Asthma with Obesity

流行病学研究显示肥胖与哮喘存在联系,表现为增加支气管哮喘发病风险、加重哮喘发作症状、加大治疗难度以及削弱哮喘一线治疗药物疗效的作用,但确切病理机制尚未明确。包括单核巨噬细胞、淋巴细胞、中性粒细胞、嗜酸粒细胞以及自然杀伤T细胞在内的多种免疫细胞及其分泌的细胞因子以及脂肪细胞分泌的脂联素、瘦素均参与了肥胖哮喘的病理过程,研究免疫细胞在肥胖合并哮喘中的作用及机制,可能为药物调控免疫细胞治疗肥胖哮喘提供新思路。

Epidemiologieal studies show that obesity is associated with asthma, with the manifestations of increased risk of bronchial asthma, aggravated asthma attack symptom, increased treatment difficulty and impaired frist-line medicines response, but the exact pathological mechanism is not clear yet. Variety of immune cells cytokines （ including mononuclear macrophage, lymphocytes, neutrophils, eosinophils and natural killer T cells） and their secreted cytokines and adiponectin and leptin secreted by fat cells are involved in the pathological process of asthma with obesity. Study on the effect and mechanisms of immunocytes in asthma with obesity may provide a new way of controling immunocytes by drugs.