炎症与鞍区肿瘤的研究进展

Research Progress in the Role of Inflammation in Sellar Tumors

鞍区包含脑垂体这一具有内分泌功能的特殊结构,鞍区肿瘤常表现出内分泌系统异常的症状,临床表现多样而复杂,患者生活质量受到严重影响。鞍区肿瘤主要包括垂体腺瘤、颅咽管瘤、生殖细胞瘤、脑膜瘤,炎症与鞍区肿瘤的研究近年来取得一定进展。白细胞介素(IL)6与垂体腺瘤细胞增殖有关,并可促进垂体生长激素瘤和垂体促肾上腺皮质激素腺瘤释放相关激素。颅咽管瘤中同样可见IL-6高表达。核因子κB在垂体腺瘤中表达水平升高。体外实验表明,环加氧酶抑制剂可抑制垂体腺瘤和脑膜瘤的增长。炎性细胞与颅咽管瘤、脑膜瘤、生殖细胞肿瘤的发生和发展相关。有关炎症与颅内生殖细胞肿瘤的研究较少,但与之类似的睾丸生殖细胞肿瘤发生机制的研究表明ILs和炎性细胞起重要作用。未来仍需更多体内试验来进一步探究炎症网络与鞍区肿瘤形成的具体作用模式,从而能研制出针对炎症过程的肿瘤治疗方法。

The sellar region is a complex and important with the presence of pituitary gland. Tumors of this region frequently lead to clinical manifestations of abnormal endocrine function and a decrease of patients＇ quality of life. Recent researchrevealeda close relationship between inflammatory processes and sellar tumors including pituitary adenoma, craniopharyngioma, germinoma and meningioma. Interletikin（IL） -6 promotes the proliferation and the hormone secretion of pituitary adenoma. Elevated IL-6 expression is also found in craniopharyngioma. The expression of muclear factor NF-κB increases in pituitary adenoma. In vitro experiments demonstrate that cyclooxygenases-2 inhibitors could suppress the growth of pituitary adenomas and meningiomas. Inflammatory cells are closely related to the tumorigenesis of craniopharyngiomas, germinoma and meningiomas. Studies on inflammation and intracranial germ cell tumors are rare, but studies of the pathogenesis of testicular germ cell tumors have shown that ILs and inflammatory ceils play an important role. In the future in vivo studies are still needed to further investigate the specific role of the inflammatory network and the formation of sellar tumors, thereby enabling the development of tumor therapies targeting the inflammatory process.