摘要
经皮冠状动脉介入(PCI)是治疗急性心肌梗死(AMI)的主要措施,但是即使成功开通心外膜冠状动脉阻塞血管也并不意味着心肌组织恢复真正有效的灌注。心肌无复流(MNR)是PCI后严重并发症,是AMI患者心脏不良心血管事件的独立预测因子,其出现提示患者临床预后不佳。目前MNR的发生机制尚不清楚,炎症、氧化应激反应在其发生过程中发挥重要作用。在AMI患者中,合并肾功能不全(RI)者心肌血流灌注明显减少,因此RI可能是MNR的独立危险因子之一。
Percutaneous coronary intervention（PCI） is one of the most effective methods to treat patients with acute myocardial infarction. However the successful opening of the epieardial coronary artery occlusion does not mean effective perfusion of myocardial tissue. Myocardial no-reflow （MNR） is one of the worst eomplieations of reperfusion, which is an independentpredietor of cardiac events in AMI patients. Currently,the pathogenesis of MNR has not been fully understood, but inflammation reaction and oxidative stress play important roles in the MNR. Myocardial blood flow perfusion is reduced in patients with renal insufllcieney（Rl） ,so RI may be an independent risk factor for MNR.
出处
《医学综述》
2017年第16期3245-3249,共5页
Medical Recapitulate
关键词
肾功能不全
心肌无复流
炎症反应
氧化应激反应
Renal insufficiency
Myocardial no-reflow
Inflammation reaction
Oxidative stress
