糖尿病肾病发病机制的研究进展

Research Progress of the Pathogenesis of Diabetic Kidney Disease

糖尿病肾病是糖尿病的主要并发症之一,是导致终末期肾功能衰竭的主要原因。糖尿病肾病的发病机制十分复杂,确切的机制仍未明确。目前认为血流动力学改变、代谢紊乱、炎症、自噬、氧化应激、微RNAs及一些病理因素参与疾病的发生与发展。虽然严格控制血糖和血压会延缓糖尿病肾病的进展,但是仍未有理想的干预措施能够逆转或者阻止糖尿病肾病的进展。因此,了解糖尿病肾病的发病机制对改善糖尿病患者的预后具有重要的意义。

Diabetic kidney disease is one of the major complications of diabetes meUitus, and it has also become the most important cause of end-stage renal failure. The pathogenesis of diabetic kidney disease is very complex, and the exact mechanism is still not clear. Until now,hemodynamic, metabolic, inflammatory, autophagy, oxidative stress, miRNA and some other pathological factors have been confirmed to participate in the occurrence and progress of the disease. Although strict control of the blood glucose and blood pressure can delay the progress of diabetic kidney disease, there are still no ideal interventionsto reverse or prevent the development of the disease so far. Therefore, understanding the pathogenesis of diabetic kidney disease has significance to improve the prognosis of patients with diabetes.