PET/CT检测冠状动脉旁路移植术患者存活心肌的研究进展

Research Progress of PET/CT Imaging for Detection of Viable Myocardium in Patients with Coronary Artery Bypass Grafting

冠心病是威胁人类健康的主要疾病之一,并已开始在发展中国家蔓延。近年来,我国冠心病发病率有明显上升趋势,且呈年轻化发展,有效地控制冠心病发作,同时提高患者的生存质量是目前需要解决的关键问题。冠状动脉旁路移植术是严重冠心病患者重要而有效的治疗手段,但并非所有冠心病患者都能从中获益,许多临床证据均表明,只有在心肌存活的情况下,血运重建术才会发挥应有的效果,因此术前对于患者存活心肌的测定,是决定治疗方案,甚至是判断预后的关键因素之一。正电子发射型计算机断层显像/X线计算机断层是评价存活心肌的无创性影像手段之一,且被国际公认为判断存活心肌的"金标准"。

Coronary heart disease is one of the major health risks, the incidence of which has showed an upward trend in developing countries and age of onset is getting younger. Obviously, it is a key issue to reduce the morbidity effectively and improve quality of life for the patients. Coronary artery bypass grafting is an important and effective treatment in patients with severe coronary atherosclerotic heart disease. However, not all such patients will benefit from it. Lots of clinical evidences have shown that the surgery will be successful only when the myocardium are viable. Thus, the decisive factor of managing therapeutic scheme and predicting prognosis is the determination of viable myocardium. Positron emission computed tomography/x-ray computed tomography（PET/CT） is a noninvasive imaging modality for evaluating the viability of myocardium and is considered to be the ＂golden standard＂.