快感缺失、压力和神经质人格对抑郁症发病的影响

Effects of Anhedonia, Stress and Neuroticism on Etiology of Major Depressive Disorder

目的:探讨快感缺失、压力、神经质人格在抑郁症发病中的作用。方法:用愉快情绪量表(TEPS)、大五人格问卷一神经质分量表(FFI-N)、Beck抑郁量表(BDI)、生活事件量表(LES)对84名抑郁症患者和75名健康对照进行调查。结果:抑郁症患者期待性快乐和消费性快乐显著低于健康对照组(P<0.05);神经质人格、BDI和应激显著高于健康对照组(P<0.01);Logistics回归分析发现消费性快乐(OR=1.10,95%CI=1.03-1.17)、神经质人格(OR=0.91,95%CI=0.83-1.00)、BDI(OR=0.93,95%CI=0.89-0.98)、负性生活事件(OR=0.94,95%CI=0.92-0.97)与抑郁症发病存在显著关联。结论:个体的消费性快乐、负性压力和神经质人格是抑郁症发病的危险因素。

Objective： To investigate the etiology of Major Depressive Disorder（MDD）, we explored the relationship of anhedonia, stress and neuroticism in MDD patients. Methods： Investigation was conducted among 84 MDD patients and 75 healthy controls by using the Temporal Experience of Pleasure Scale（TEPS）, Five-Factor Inventory-Neuroticism（FFI-N）,Beck Depression Inventory（BDI） and Live Events Scale（LES）. Results： Compared with healthy controls, MDD patients exhibited significantly lower scores on anticipatory pleasure, consummatory pleasure（P〈0.05） and higher scores on neuroticism, BDI and stress（P〈0.05）. Logistics Regression analysis showed that consummatory pleasure（OR=1.10, 95%CI=1.03-1.17）, neuroticism（OR=0.91, 95% CI=0.83-1.00）, BDI（OR=0.93, 95% CI=0.89-0.98） and negative life events（OR=0.94,95%CI=0.92-0.97） had significant impact on MDD patients. Conclusion： These findings suggest that consummatory pleasure, negative stress, neuroticism are risk factors in Major Depressive Disorder.