摘要
胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)是由远端回肠、结肠的L细胞分泌的具有促进胰岛素分泌作用的肠促胰岛素,近20年的研究表明,GLP-1除了具有维持葡萄糖稳态的作用外,在调节胃肠道动力和相关胃肠疾病中也发挥着重要作用。研究表明,GLP-1对胃肠道动力主要起抑制作用,其机制可能与胆碱能迷走神经及一氧化氮(nitric oxide,NO)释放有关。在消化道疾病方面,GLP-1可能参与肠易激综合征(irritable bowel syndrome,IBS)、炎症性肠病(inflammatory bowel disease,IBD)、短肠综合征(short bowel syndrome,SBS)等发病,并在治疗中发挥重要作用。本文就GLP-1与消化道动力的关系及机制,及其在相关疾病中的作用等作一综述。
Glucagon-like peptide-1 ( GLP-1 ) is an incretin which is secreted by the distal ileum, colon and rectum L cells, and it also can promote the secretion of insulin. Recent 20 years studies have showed that GLP-1 not only has the effect maintain glucose homeostasis, but also plays an important role in regulating gastrointestinal motility and related gastrointestinal disease. GLP-1 plays a major role in the inhibition of gastrointestinal motility, and its mechanism may be related to the cholinergic vagal and nitric oxide (NO) release. In terms of gastrointestinal diseases, GLP-I may be in- volved in the pathogenesis of irritable bowel syndrome (IBS) , inflammatory bowel disease (IBD), short bowel syndrome (SBS) and other diseases, and it may play an important role in the treatment. This article reviewed the advanced study on GLP-1 in the function and mechanism of the gastrointestinal tract.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第8期944-947,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
湖北省自然科学基金项目(2013CFA128)
关键词
胰高血糖素样肽-1
胃肠动力
消化道疾病
Glucagon-like peptide-1
Gastrointestinal motility
Gastrointestinal diseases