口腔微生物与不良妊娠结局关系的研究进展

Research Progress of Relationship Between Oral Organisms and Adverse Pregnancy Outcomes.

长久以来,胎盘一直被认为是无菌环境,但最新研究采用分子生物学技术,发现胎盘内同样存在其独特的微生物群落,且与口腔微生物群落最为接近。经血行途径散播的口腔致病菌已成为宫内感染的另一重要来源。本文就近年来国内外对口腔微生物入侵子宫的研究及其对不良妊娠结局(adverse pregnancy outcomes,APOs)的影响进行探讨,为孕妇口腔疾病的预防和临床治疗提供新的方向。

The placentas of healthy pregnancies were always considered to be bacteria-free environment.But novel findings characterized a unique microbiome niche in the placenta with molecular approaches,which may be most akin to the human oral microbiome.The increased oral bacteria detection in placental tissue,suggesting a hematogenous spread of bacteria that originates from oral microflora may be associated with intrauterine infection.The article aims to review current researches about the microbe from oral cavity invade the placenta and its potential relationship with adverse pregnancy outcomes（APOs）.