甲钴胺治疗糖尿病神经病变的效果观察

Effect of Mecobalamin treating diabetic neuropathy

目的探讨甲钴胺治疗糖尿病神经病变的效果。方法选取2015年3月~2016年7月在本院接受治疗的糖尿病神经病变患者74例,将患者随机分组为对照组与观察组,每组37例。对照组患者接受常规治疗,观察组在常规治疗的同时采用甲钴胺治疗。比较两组患者的临床疗效及功能改善、神经传导速度、血糖水平以及不良症状改善情况。结果观察组患者的总有效率为94.59%,高于对照组的75.68%(P<0.05)。观察组患者的左肱二头肌、右肱二头肌、左膝腱反射以及右膝腱反射改善率均明显高于对照组(P<0.05)。治疗后,观察组患者的尺神经运动神经、尺神经感觉神经、腓神经运动神经及腓神经感觉神经传导速度均较治疗前传导速度改善,且观察组的改善幅度大于对照组(P<0.05)。治疗后,两组患者的空腹血糖、餐后2 h血糖水平均明显低于治疗前,且观察组治疗后的上述指标低于对照组(P<0.05)。观察组的发肢痛、麻木、发热、发冷、感觉减退、腹泻、多汗、排便困难改善率均明显高于对照组(P<0.05)。结论甲钴胺治疗糖尿病神经病变可明显改善患者的功能与神经传导速度,有效控制血糖,具有较高的安全性,值得临床广泛应用。

Objective To observe the effect of Mecobalamin treating diabetic neuropathy.Methods A total of 74 patients with diabetic neuropathy treated in our hospital from March 2015 to July 2016 were selected and they were divided in- to the control group and observation group,and there were 37 cases in each group.The control group received the rou- tine treatment while the observation group was treated with Mecobalamin on the basis of the control group.The clinical efficacy and the improvement of function,the nerve conduction velocity,blood sugar level and adverse symptoms between the two groups were compared.Results The total effective rate of the observation group was 94.59%,which was higher than that of the control group （75.68%） （P〈0.05）.The improvement rate of left bicipital muscle of arm,right bieipital muscle of arm, tendon reflex of left knee and tendon reflex of right knee were higher than those of the control group （P〈0.05）.After treatment,the conduction velocity of ulnar nerve motor nerve, ulnar nerve sensory nerve, peroneal nerve motor nerve and peroneal nerve in patients of the observation group were significantly improved compared with before treatment and the improvement range in the observation group was larger than that of the control group （P〈0.05）.After treatment,fasting blood glucose and postprandial blood glucose levels of 2 h in the two groups were significantly lower than before treatment,and the above-mentioned indexes in the observation group after treatment were lower than those of the control group （P〈0.05）. The improvement rate of limb pain,numbness,fever,chills,hypoesthesia,diarrhea,sweating, difficult defecation in the observation group were significantly higher than those of the control group （P〈0.05）.Conclu- sion Methylcobalamin treating diabetic neuropathy can significantly improve the patients＇ function and nerve conduc- tion velocity,effective control the blood sugar, and has a high safety,it is worthy of clinical wide application.