前列地尔联合丹参川芎嗪治疗腔隙性脑梗死眩晕的临床效果

Clinical effect of Alprostadil combined with Salviaemiltiorrhizae and Ligustrazine in the treatment of vertigo due to lacunar infarction

目的研究中药针剂丹参川芎嗪联合前列地尔(PGE1)治疗腔隙性脑梗死(LI)眩晕的效果。方法选择我院2015年8月~2017年4月治疗的117例LI患者,随机分为PGE1组(59例)和联合组(58例)。联合组使用中药针剂丹参川芎嗪联合PGE1治疗,PGE1组采用PGE1治疗。对比两组的疗效以及脑血流情况,包括基底动脉、右椎动脉及左椎动脉血流。结果联合组的总有效率为91.38%,高于PGE1组的77.97%,差异有统计学意义(P<0.05)。联合组的脑血流速度显著高于PGE1组,差异有统计学意义(P<0.05)。结论联合中药复方制剂丹参川芎嗪与PGE1治疗LI眩晕的疗效确切。

Objective To study the effect of injection of Salviaemiltiorrhizae and Ligustrazine combined with Alprostadil （PGE1） on treating vertigo due to lacunar infarction （LI）.Methods From August 2015 to April 2017,117 LI patients treated in our hospital were selected and randomly divided into the PGE1 group （n=59） and the combination group （n= 58）.In the combination group,injection of Salviaemiltiorrhizae and Ligustrazine was selected for treatment,while in the PGE1 group,PGE1 was adopted.The effect on treating vertigo and cerebral blood flow including basilar artery,right ver- tebral artery,and left vertebral artery blood flow were compared in the two groups.Results The effective rate in the com- bined group was 91.38%,which was higher than that in the PGE1 group accounting for 77.97%,with statistical differ- ence （P〈0.05）.The cerebral blood flow velocity in the combined group was significantly faster than that in the PGE1 group,with significant difference （P〈0.05）.Conclusion The combination of traditional Chinese herbal medicine com- pound preparation of Salviaemihiorrhizae and Ligustrazine combined with PGE1 can obtain a definite effect on treating vertigo due to LI.