糖尿病合并脑梗死患者血清心型脂肪酸结合蛋白与神经功能缺损程度的相关性

The correlation between heart-type fatty acid-binding protein and the degree of nervous function defect in patients with diabetes mellitus complicated with cerebral infarction

目的探讨糖尿病合并脑梗死患者血清心型脂肪酸结合蛋白(H-FABP)与神经功能缺损程度的相关性。方法选取70例2型糖尿病合并脑梗死患者为研究对象,以70例单纯糖尿病患者(无合并脑梗死)为对照。根据NIHSS评分将脑梗死组分为轻度、中度和重度组,应用ELISA法检测全部受试者血清H-FABP水平。比较各亚组间血清H-FABP水平的差异,分析H-FABP与NIHSS评分、梗死灶面积的相关性。结果大病灶、中等病灶和小病灶组的H-FABP水平均高于对照组,组间差异有统计学意义(P<0.05)。NIHSS评分轻度、中度和重度组的血清H-FABP水平差异有统计学意义,随着患者神经功能缺损程度的加深,H-FABP水平逐渐升高。相关性分析显示血清H-FABP浓度与NIHSS评分、梗死灶面积呈显著正相关。结论糖尿病合并脑梗死患者血清H-FABP水平显著升高,且与神经功能缺损程度呈正相关。

Objective To study the correlation between heart-type fatty acid-binding protein （H-FABP） and the degree of nervous function defect in patients with diabetes mellitus complicated with cerebral infarction. Methods The 70 patients with type 2 diabetes mellitus cerebral infarction were selected as research objects,and 70 diabetic patients without cerebral infarction were selected as the control group. According to the NIHSS score, the cerebral infarction group was divided irltO mild group,moderate group and severe group. According to the size of the infarction area,the patients were divided into serious lesion group,moderate lesion group and small lesion group. ELISA was used to detect the serum H-FABP levels. The difference of serum H JFABP levels among different subgroups was compared. The correlation between H-FABP and NIHSS score and infarct size was analyzed. Results The level of H-FABP in the serious,miderate and small lesions was higher than that in the control group,the difference between the three groups was statistically significant（P〈0.05）. The serum levels of H- FABP in moderate,mild and severe groups were statistically significant. The level of H-FABP was significantly increased with the increase of the degree of neurological deficits. The level of H-FABP had significantly positive correlation with NIHSS score and infarction size. Conclusion The level of H-FABP in patients with diabetes mellitus complicated with cerebral infarction is significantly increased,which is closely related to the degree of neurological deficits.