肤康止痒洗剂治疗足浅部真菌病临床观察及其抑菌试验研究

Study on the Clinical Observation and Bacteriostatic Test of Fukang Zhiyang Lotion in the Treatment of Foot Superficial Fungal Disease

目的研究中药肤康止痒洗剂治疗足浅部真菌病临床疗效及其抑菌效果。方法选取2014年5月—12月足浅部真菌病患者120例,随机分两组。常规组采用萘替芬酮康唑乳膏进行外用治疗,联合治疗组先用中药肤康止痒洗剂浸泡,后用萘替芬酮康唑乳膏进行外用治疗。比较两组患者足浅部真菌病治疗总有效率;真菌清除率;平均治愈时间、不良反应发生率;治疗前后患者临床症状和体征评分、生活质量评分的差异。结果联合治疗组患者足浅部真菌病治疗总有效率高于常规组,P<0.05;联合治疗组患者真菌清除率高于常规组,P<0.05;联合治疗组平均治愈时间短于常规组,P<0.05;两组不良反应发生率无显著差异,P>0.05;治疗前两组临床症状和体征评分、生活质量评分比较无显著差异,P>0.05;治疗后联合治疗组临床症状和体征评分、生活质量评分改善幅度更大,P<0.05。结论中药肤康止痒洗剂治疗足浅部真菌病临床疗效确切,抑菌作用确切,可有效改善患者临床症状和体征,清除真菌,缩短治疗时间,促进患者生活质量的提高,且无严重不良反应发生,安全性高,可在临床推广和应用。

Objective To study the clinical curative effect and bacteriostatic effect of Chinese medicine Fukang Zhiyang lotion in the treatment of foot superficial fungal disease. Methods 120 cases of foot mycosis from May 2014 to December 2014 were randomly divided into two groups. The conventional group used Naftifine Hydrochloride and Ketoconazole cream topical therapy. The combined therapy group was treated with Chinese medicine Fukang Zhiyang lotion after cleaning with Naftifine Hydrochloride and Ketoeonazole cream for topical treatment. The effective rate, the fungal clearance rate, the average cure time and incidence rate of adverse reaction, the difference of clinical symptoms and signs score and life quality score before and after treatment was compared, respectively. Results The effective rate of the combined therapy group was higher than that of the conventional group, P 〈 0.05. The fungal clearance rate of the combined therapy group was higher than that of the conventional group, P 〈 0. 05. The average healing time of the combined therapy group was shorter than that of the conventional group, P 〈 0. 05. The incidence of adverse reactions between the two groups had no significant difference P 〉 0. 05. Before treatment, the clinical symptoms and signs score and life quality score between the two groups had no significant difference, P 〉 0. 05. After treatment, clinical symptoms and signs score, quality of life scores of the combined therapy group improved more significantly, P 〈 0. 05. Conclusion Chinese medicine Fukang Zhiyang lotion in the treatment of foot superficial fungal disease has exactly clinical curative effect and antibacterial effect, can effectively improve the clinical symptoms and signs, remove fungi, shorten treatment time, improve the patient＇ s quality of life, and has no serious adverse reaction, has high safety, and can be popularized in clinical application.