中药联合常规西药治疗重症病毒性心肌炎的临床观察

Clinical observation of Traditional Chinese Medicine Combined with Conventional Western Medicine in the Treatment of Severe Viral Myocarditis

目的研究重症病毒性心肌炎患者采用中药联合常规西药的临床治疗效果以及安全性。方法选取2015年4月—2016年10月重症病毒性心肌炎患者68例,随机分两组。西药治疗组采用常规西药治疗,中西药治疗组采用中药联合常规西药的用药方案。比较两组重症病毒性心肌炎患者治疗总有效率;药物不良反应发生率;治疗前后患者乳酸脱氢酶,心肌钙蛋白I、T活性,肌酸激酶同工酶的差异。结果中西药治疗组患者重症病毒性心肌炎治疗总有效率高于西药治疗组,P<0.05;两组均无严重不良反应发生,P>0.05;治疗前两组乳酸脱氢酶,心肌钙蛋白I、T活性,肌酸激酶同工酶比较无显著差异,P>0.05;治疗后中西药治疗组乳酸脱氢酶,心肌钙蛋白I、T活性,肌酸激酶同工酶改善幅度更大,P<0.05。结论重症病毒性心肌炎患者采用中药联合常规西药的用药方案,临床效果确切,安全性高,无严重不良反应,可有效改善患者心肌酶谱,值得推广。

Objective To study the clinical effect and safety of traditional Chinese medicine combined with Western medicine in the treatment of severe viral myocarditis. Methods 68 cases of patients with severe viral myocarditis from April 2015 to October 2016 were randomly divided into two groups. The Western medicine treatment group was treated with conventional Western medicine. The traditional Chinese medicine and Western medicine treatment group was treated with traditional Chinese medicine combined with Western medicine. The total effective rate, the incidence of adverse drug reactions, differences in patients with LDH, cardiac troponin I and creatine kinase isoenzyme and T activity before and after treatment was compared. Results The total effective rate of the traditional Chinese medicine and Western medicine treatment group was higher than that of the Western medicine treatment group P 〈 0.05. There were no serious adverse reactions between two groups P 〉0. 05. Before treatment, LDH, cardiac troponin I and ereatine kinase isoenzyme, T activity i,：twcen the two groups had no significant difference P 〉 0.05. After treatment, lactate dehydrogenase, cardiac troponin I and creatine kinasc isoenzyme, T activity of the traditional Chinese medicine and Western medicine treatment group improved more significantly P 〈 0.05. Conclusion The traditional Chinese medicine combined with Western medicine in the treatment of severe viral myocarditis has definitely clinical effect and high safety, no serious adverse reactions, can effectively improve myocardial enzymes, and it is worthy of promotion.