七氟烷联合丙泊酚对老年腹腔镜宫颈癌切除术患者术后认知功能及血清SOD水平影响研究

Effect of Sevoflurane combined with Propofol on postoperative cognitive function and serum SOD level in elderly patients undergoing laparoscopic resection of cervical cancer

目的评价七氟烷联合丙泊酚对老年腹腔镜宫颈癌切除术患者术后认知功能及血清SOD水平影响研究。方法 60例老年宫颈癌患者随机分为对照组及试验组,各30例。所有患者均给予腹腔镜下宫颈癌切除术治疗,对照组给予1%~3%的七氟烷吸入进行麻醉维持;试验组在对照组基础上加用丙泊酚3.0 mg/(kg·h)靶控输注。比较两组患者手术前后血清中枢神经特异蛋白(S100β)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平、简易智能精神状态量表(MMSE)评分及安全性。结果治疗后,与对照组比较,试验组患者血清SOD水平较高,MDA水平较低(P<0.05)。试验组患者血清S100β水平较低,MMSE评分较高(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论七氟烷联合丙泊酚能够防止血清SOD水平下降,减轻氧化应激反应,对老年腹腔镜宫颈癌切除术患者术后认知功能的影响较小,且安全性较高。

Objective To evaluate the effect of Sevoflurane combined with Propofol on postoperative cognitive function and serum SOD level in elderly patients with laparoscopic resection of cervical cancer. Methods Sixty elderly patients with cervical cancer were randomly divided into control group and treatment group, each with 30 cases. All patients were treated with laparoscopic radical resection of cervical cancer. The patients of both groups were given 1%-3% Sevoflurane by inhalation, and the experimental group was added with Propofol 3.0 mg/（kg·h） by target controlled infusion. Serum levels of central nervous specific protein （S100β）, superoxide dismutase （SOD） and malondialdehyde （MDA）, Mini Mental State Scale （MMSE） score and safety were compared between the two groups before and after operation. Results After treatment, compared with the control group, the serum level of SOD was higher, and the serum level of MDA was lower in the experimental group （P〈 0.05）; the serum level of S100β was lower, and the MMSE score was higher in the experimental group （P〈 0.05）; there were no significant differences in the incidences of adverse reactions between the two groups （P 〉 0.05）.Conclusions Sevoflurane combined with Propofol can prevent the decrease of serum SOD level, reduce oxidative stress reaction, has little effect on the postoperative cognitive function of the elderly patients with laparoscopic resection of cervical cancer, and also has high safety.