蛋白质组学在细胞信号通路研究中的应用

Applications of proteomics in the study of cell signal pathways

细胞中各种信号转导与生物学过程密切相关,而蛋白质在信号传导过程中起着至关重要的作用。蛋白质组学从整体水平上研究蛋白质组,可系统地研究生物体生理生化以及与疾病发生发展相关的功能性蛋白的表达,是研究细胞信号通路的有效方法之一。目前,蛋白质组学技术已经应用于各种信号通路研究中,并取得了诸多进展。本文综述了蛋白质组学在肝脏疾病、肿瘤、病原微生物致病机制以及机体代谢相关通路的研究等方面的应用,以期为蛋白质组学在相关领域的进一步应用研究提供参考。

Various signal transduction pathways in cells are closely related to the biological processes, while the proteins play an important role in the process of signal transductions. Proteomics, which is one of the effective methods for the study of cell signal pathways, can conduct proteomic analysis systematically as well as explore the expression of functional proteins related to the physiological characteristics in organism and in the initiation and progression of diseases. Nowadays, proteomics has been successfully applied in the studies of many kinds of signal pathways. In this paper, proteomic study in signal pathways related to liver disease, tumors, pathogenic mechanism of pathogens and metabolism are reviewed, in order to provide a reference for future research and applications of proteomics in the related fields.