吡格列酮治疗2型糖尿病的疗效及安全性的临床观察

Clinical Observation of Efficacy and Safety of Pioglitazone in the Treatment of Type 2 Diabetes Mellitus

目的分析吡格列酮在治疗2型糖尿病的疗效。方法选取该院收治的2型糖尿病患者88例,随机分为两组,一组给予服用常规降糖药物磺酰脲类、双胍类、α糖苷酶抑制剂等进行治疗,另一组在此基础上在服用吡格列酮进行治疗,对比两组治疗前后胆固醇(TC)﹑三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、肝功能等。结果两组患者进行比较结果 ,试验组在降血糖方面的疗效更佳,在空腹血糖和餐后2 h血糖方面都有明显的降低。差异有统计学意义(P<0.05)。结论吡格列酮可以更好的控制2型糖尿病患者的血糖,并未发现不良反应。

Objective This paper tries to analyze the efficacy of pioglitazone in the treatment of type 2 diabetes mellitus. Methods 88 cases of patients with type 2 diabetes in this hospital were selected and randomly divided into two groups, one group was given conventional hypoglycemic drug like the sulfonylurea, biguanides, alpha glucosidase inhibitor treatment, and the other group added pioglitazone treatment, cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, fasting blood glucose （FPG）, 2 h postprandial blood glucose （2 hPG） and the liver function of the two groups before and after treatment were compared. Results The results of the two groups were compared. The experimental group per -formed better in reducing blood glucose, and fasting blood glucose and 2h postprandial blood glucose. The difference were statistically significant （P〈0.05）. Conclusion Pioglitazone can better control the blood glucose in patients with type 2 dia -betes mellitus and no adverse reactions happen.