孕期摄入咖啡因与低出生体质量新生儿风险的研究进展

Maternal caffeine consumption during pregnancy and the risk of low birth weight

低出生体质量与新生儿死亡率升高及成年后慢性疾病相关.研究表明,孕期摄入咖啡因很可能与胎儿低出生体质量关系密切.咖啡因可能通过阻断腺苷受体、抑制磷酸二酯酶及增强血管紧张素Ⅱ受体基因表达等机制使胎盘血流减少,导致低出生体质量.提示孕期女性应注意控制咖啡因的摄入量.

Low birth weight is associated with newborn mortality and adult chronic diseases.Some studies found that naternal caffeine consunption during pregnancy was closely related with low birth weight.Resent research evidence indicates that caffeine may induce low birth weight by blocking adenosine receptors,inhibiting phosphodiesterase（PDE） and enhancing angiotensin Ⅱ （AT2） receptor gene expression to lower the placenta blood flow.We recommend that women should reduce caffeine intake during pregnancy.