咽喉反流和喉癌前病变

Laryngopharyngeal reflux disease and laryngeal precancerous lesions

咽喉反流性疾病（laryngopharyngeal reflux disease,LPRD）是胃内容物反流至食管上括约肌以上部位引起的一系列症状和体征的总称.近年来,咽喉反流（laryngopharyngeal reflux,LPR）作为喉癌前病变及喉癌的危险因素受到越来越多的关注.在喉癌发生发展的过程中,喉癌前病变是一个不容忽视的阶段.本文将就LPR在喉癌前病变发生中的作用、机制,以及抗反流在喉癌前病变治疗中的地位进行综述.

The laryngopharyngeal reflux disease （LPRD） is a general term for a series of symptoms and signs caused by reflux of the stomach contents to the upper part of the esophageal sphincter.In recent years, the laryngopharyngeal reflux （LPR） is getting more and more attention as laryngeal precancerous lesions and risk factors of laryngeal cancer.Laryngeal precancerous lesions plays a important role in the development of laryngeal cancer process.This article will review the role and mechanisms of LPR in the laryngeal precancerous lesions, and the status of anti-reflux in the treatment of laryngeal precancerous lesions.