骨膜蛋白与代谢相关性疾病的关系

Relationship between Periostin and Metabolic Diseases

骨膜蛋白是属于成束蛋白家族成员的一种细胞外基质蛋白,可表达于人体多种组织器官,参与骨组织分化发育、肿瘤生成转移、心肌梗死后修复以及炎症性疾病等的病理生理过程。骨膜蛋白参与糖尿病发生、发展的过程,影响糖脂代谢以及胰岛素抵抗,与糖尿病并发症、脂肪肝、肥胖关系密切,此外骨膜蛋白与大血管病变也相关。骨膜蛋白为一种分泌型蛋白质,有望成为疾病的治疗靶标和检测指标,用于疾病的早发现、早诊治、早治疗,其具有广阔的应用前景。

Periostin is an extracellular matrix protein that belongs to the fasciclin family, which can be expressed in multiple tissues and organs, and participates in a variety of pathophysiological process of bone tissue differentiation and development, tumor metastasis, repair of myocardial infarction and inflammatory disease. Periostin is reported to be involved in the development and progression of diabetes,impacting glycolipid metabolism and insulin resistance, and to be a critical regulator participating in diabetes complications ,fatty liver disease and obesity, meanwhile, periostin is also associated with macrovascular disease. Periostin as a secreted protein, is promising to become a diagnosis biomarker and an excellent thera- peutic target for the clinical diseases, for guiding the early detection, early diagnosis and treatment, which will have broad application prospects.