精神心理障碍与胃食管反流疾病共病的研究进展

Research Progress of Comorbidity between Mental and Psychological Disorder and Gastroesophageal Reflux Diseases

近年来,胃食管反流疾病(GERD)因其发病率高、病程长、对患者的生存质量影响大及病因未完全明确而受到越来越多的关注。其反复发作的特性使得长时间的GERD患者往往产生抑郁、焦虑等精神心理障碍,而精神心理障碍人群容易产生胃肠道慢性疾病,如GERD。临床上,对GERD患者常辅以抗焦虑等精神疾病药物治疗,且取得了较好疗效。目前,对GERD和精神心理障碍共病的研究还处于探索阶段,其确切机制尚不明确。因此,明确两者之间是否存在共同的作用介质或途径显得尤为重要,这将为疾病的治疗提供更好的治疗靶点。

In recent years, gastroesophageal reflux disease （GERD） because of its high incidence, long duration, large impact on patients quality of life and unclear etiology, has drawn more and more attention. In view of its characteristics of the repeated attacks, patients with long time suffering from GERD tend to have mental disorders such as depression, anxiety, and on the other hand, patients with mental disorders are often prone to chronic gastrointestinal diseases such as GERD. In clini- cal, anti-anxiety and mental disorders drugs are used in patients with GERD and have achieved good results. At present, the study of comorbidity of GERD and mental disorders is still in the exploratory stage, and the exact mechanism is not clear. Therefore, it is important to make clear whether there is a .common role, media or pathway between the two, which will pro- vide better therapeutic targets for the treatment.