甲氨蝶呤与Th17/Treg细胞平衡对类风湿关节炎的作用机制研究

Methotrexate and Th17/Treg Balance in the Pathogenesis of Rheumatoid Arthritis

类风湿关节炎(RA)是一种慢性进行性的自身免疫性疾病,探讨其发病机制是RA研究中的重要部分。免疫功能紊乱、遗传、环境因素等均与RA的发病相关。免疫功能紊乱是RA发病的主要原因,而辅助性T细胞(Th)17/调节性T细胞(Treg)的平衡、失衡及相关细胞因子均在RA的发病及病情进展中具有重要作用。甲氨蝶呤作为治疗RA的一线药物,其治疗机制也与Th17/Treg细胞的平衡及失衡有关,通过纠正Th17/Treg细胞失衡,从而改善RA的炎症反应,可为RA的进一步治疗提供理论思路。

Rheumatoid arthritis （RA） is a chronic progressive autoimmune disease, and its pathogenesis is an impor- tant part of RA research. Immune dysfunction, genetic background, environment are related to RA onset. Immune dysfunction is the main cause of RA, and the balance, imbalance and associated cytokines of helper T cells （Th） 17/regulatory T cells （Treg） play an important role in the onset and progression of RA. Methotrexate as a first-line drug for the treatment of RA, the treatment mechanism is also associated with Thl7/Treg cell balance and imbalance,so correcting Thl7/Treg imbalance thereby improving the inflammatory response of RA,provides further theories for further treatment of RA.