贫血对糖化血红蛋白影响的研究进展

Research Progress in the Effect of Anemia on Glycosylated Hemoglobin

糖尿病患者长期处于高血糖状态,可通过产生糖基化终末产物引起血管内皮损伤、细胞间基质增殖等最终造成多系统脏器功能衰竭,甚至危及生命。目前糖化血红蛋白(Hb A_(1c))作为诊断糖尿病及长期血糖监测的重要指标已得到广泛认可,并可预测糖尿病患者并发症发生风险。然而贫血性疾病,如缺铁性贫血、溶血性贫血、再生障碍性贫血等可通过缩短红细胞寿命、改变血红蛋白结构、增加血红蛋白与葡萄糖结合率等可明显降低HbA_(1c)检测结果的准确性。因此,探究贫血性疾病对HbA_(1c)检测影响的机制,对糖尿病的诊断、治疗及延缓慢性并发症的发生起到至关的重要作用。

The patients with diabetes mellitus are in a state of hyperglycemia for a long time, which can be produced by glycesylatiou end products, and then can cause vascular endothelial injury and proliferation of stromal cells, finally leading to multi-system organs failure,and can even be life-threatening. The glyeesylated hemoglobin （ HbAlo ） as one of the important indices for diagnosis of diabetes and long-term blood sugar monitoring has been widely recognized ,which can predict the risk of diabetes complications. However, anemia, sexual diseases, such as iron deficiency anemia, hemolytic anemia, aplastic ane- mia, etc. , can shorten RBC life, change the structure of hemoglobin, increase the rate of hemoglobin and glucose, etc. , and obviously reduce the accuracy of testing results of HbAlo. Therefore, exploring the mechanism of anemia on the detection of HbAlo plays an important role in the diagnosis and treatment of diabetes and delaying the occurrence of chronic complications.