黄连素联合利培酮治疗对精神分裂症患者内分泌激素、氧化应激程度的影响

Effect of berberine combined with risperidone therapy on endocrine hormones and oxidative stress in patients with schizophrenia

目的:探讨黄连素联合利培酮治疗对精神分裂症患者内分泌激素、氧化应激程度的影响。方法:收集2014年5月~2016年5月在本院接受治疗的精神分裂症患者90例,回顾治疗方案并将入组患者分为:接受利培酮治疗的对照组47例,接受黄连素联合利培酮治疗的观察组43例,对比两组患者治疗前后血清中胰岛素抵抗指标水平,甲状腺激素、催乳素含量,氧化应激指标含量的差异。结果:治疗前,两组患者血清中岛素抵抗指标水平,甲状腺激素、催乳素含量,氧化应激指标含量的差异无统计学意义(P>0.05)。治疗后,观察组患者血清中空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)的水平低于对照组患者;血清中三碘甲状腺原氨酸(T3)含量高于对照组患者,催乳素(PRL)含量低于对照组患者;血清中丙二醛(MDA)含量低于对照组患者,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)含量高于对照组患者(P<0.05)。结论:精神分裂症患者接受黄连素联合利培酮治疗,不会造成严重内分泌激素水平紊乱,且有助于降低患者的全身氧化应激反应。

Objective：To study the effect of berberine combined with risperidone therapy on endocrine hormones and oxidative stress in patients with schizophrenia.Methods：A total of 90 patients with schizophrenia who were treated in our hospital between May 2014 and May 2016 were collected,reviewed and then divided into control group（n=47）who received risperidone therapy and observation group（n=43）who received berberine combined with risperidone therapy.Serum insulin resistance index levels,thyroid hormone and prolactin contents as well as oxidative stress index contents before and after treatment were compared between two groups of patients.Results：Before treatment,differences in serum insulin resistance index levels,thyroid hormone and prolactin contents as well as oxidative stress index contents were not statistically significant between two groups of patients（P〈0.05）.After treatment,serum FINS and HOMA-IR levels in observation group were significantly lower than those in control group;serum T3 content was higher than that in control group while PRL content was significantly lower than that in control group（P〈0.05）;serum MDA content was significantly lower than that in control group while SOD,GSH-Px and CAT contents were significantly higher than those in control group（P〈0.05）.Conclusions：Berberine combined with risperidone therapy used for patients with schizophrenia will not cause severe endocrine hormone level disorder,and it will help to reduce the systemic oxidative stress response.