2013—2015年潍坊市疑似预防接种异常反应监测分析

Analysis on surveillance of AEFI from 2013 to 2015 in Weifang City

目的了解2013—2015年潍坊市疑似预防接种异常反应(adverse events following immunization,AEFI)的发生特征,评价AEFI监测系统和疫苗预防接种的安全性。方法通过AEFI信息管理系统收集2013—2015年潍坊市AEFI个案数据,采用描述性流行病学方法对AEFI监测数据进行分析,并对AEFI监测指标进行评价。结果2013—2015年潍坊市共报告AEFI 4 737例,报告发生率为45.75/10万剂次,全市AEFI覆盖率达100%;其中一般反应4 702例,占99.26%;异常反应32例,占0.68%;偶合症3例,占0.06%。年均AEFI各项监测指标均>90%,AEFI多发生在48 h内,占85.24%。各月均有AEFI报告,昌乐县位居全市报告首位(17.29%),且主要集中在<2岁儿童,占75.53%,其中3~5月龄儿童占<1岁报告例数的42.85%。涉及29种疫苗,吸附无细胞百白破疫苗AEFI发生率最高,占28.19%。结论 2013—2015年潍坊市AEFI监测灵敏性较高,疫苗安全性良好,需进一步加强AEFI监测工作,严格掌握接种禁忌证,减少AEFI发生。

Objective To understand the characteristics of Adverse Events Following Immunization（AEFI） from 2013 to2015 in Weifang City,and to evaluate the operation of AEFI monitoring system and the safety of vaccination. Methods The AEFI data were collected from the AEFI information management system and analyzed by descriptive epidemiological method during 2013—2015 in Weifang City. Results A total of 4 737 cases were collected with an incidence 45.75/105 doses,the AEFI coverage rate was 100% in the City,including 4 702 cases with general reaction accounted 99. 63% in total AEFI,32 cases of abnormal reaction accounted 0.68%,3 cases were in coincidence accounted 0.06%. The all of annual monitored indexes were90%. The AEFI cases reported within 48 h was 85.24%,and the cases occurred in every month,the highest incidence was in Changle County accounted 17.29%. The cases in age 3 to 5 months accounted 42.85% in cases≤1 year age. The inoculation involved related 29 kinds of vaccines,among which DPa T caused the highest AEFI. Conclusion The AEFI monitoring system performed in a highly sensitive state,and the inoculation by related vaccines had good safety. AEFI surveillance should be further strengthened and contraindications strictly controlled,so as to reduce the occurrence of AEFI in Weifang City.