干姜药材的化学成分研究

Study on Chemical Constituents from Zingiberis Rhizoma

目的:研究干姜的化学成分。方法:采用硅胶、Sephadex LH-20柱色谱和薄层色谱对干姜化合物进行分离纯化,根据理化性质和波谱数据分析鉴定化合物结构。结果与结论:从干姜中分离得到5个化合物,分别鉴定为甲基-6-姜酚(1)、4-姜酚(2)、β-桉醇(3)、2,5-二羟基没药烷-3,10-二烯(4)、6-姜脑(5),化合物2、3、4为首次从干姜中分离得到。

OBJECTIVE： To study the chemical constituents of Zingiberis Rhizoma. METHODS： The compounds of Zingiberis Rhizoma were classified and purified by silica gel, Sephadex LH-20 column chromatography and thin layer chromatography （TLC）. The structure of compounds were analyzed and identified according to chemical property and spectrum data. RESULTS ＆ CONCLUSIONS： Five compounds were isolated from Zingiberis Rhizoma, i.e. methyl-6- gingerol （1）, 4- gingerol （2）, β-eudes- mol （3）, 2, 5-dihydroxybisabola-3, 10-diene （4）, 6-shogaol （5）. The compounds 2, 3, 4 are isolated from Zingiberis Rhizoma for the first time.