磷酸铝凝胶在溃疡性结肠炎治疗中临床疗效分析

The Analysis of Clinical Efficacy of Aluminium Phosphate Gel in the Treatment of Ulcerative Colitis

目的利用临床病例对溃疡性结肠炎患者在采用磷酸铝凝胶后的临床治疗效果进行探究。方法选取该院2014年6月—2015年6月期间符合2000年全国炎症性肠病会议修订的炎症性肠病诊治规范建议的84例溃疡性结肠炎患者为研究对象,均匀分成两组,各42例。所有患者均在口服美沙拉嗪后进行结肠保留灌肠治疗,其中对照组采用氯化钠溶液添加地塞米松来进行灌肠,而实验组在采用对照组的灌肠液的同时再添加磷酸铝凝胶来进行灌肠,随后对两组患者的临床治疗效果进行对比。结果该次研究结果显示,实验组患者治疗总有效率为38例(90.48%),明显高于对照组32例(76.19%),差异有统计学意义(P<0.05);治疗后实验组DAI为(3.22±1.16)分,明显高于对照组(2.45±1.58)分,差异有统计学意义(P<0.05);实验组患者腹痛、腹泻、里急后重、便血症状改善时间分别为(3.4±0.3)、(3.8±0.6)、(3.6±0.6)、(5.3±0.6)d,明显优于对照组对应数据:(3.6±0.5)、(4.0±0.7)、(5.8±0.3)、(8.6±0.7)d,差异有统计学意义(P<0.05)。结论对溃疡性结肠炎患者进行结肠保留灌肠治疗时,采用添加磷酸铝凝胶的灌肠液,能够提高患者的治疗效果,还能缩短患者康复时间,且能达到显著的临床效果,值得在临床上推广。

Objective To study the clinical effect of aluminum phosphate gel in treatment of patients with inflammatory bowel disease. Methods 84 cases of patients with inflammatory bowel disease meeting the diagnosis and treatment standards and suggestions of inflammatory bowel disease revised by the national inflammatory bowel disease conference in our hospital from June 2014 to June 2015 were selected as the research objects and divided into two groups with 42 cases in each, both groups adopted the herbal retention enema treatment after takin the mesalazine orally, the control group used the sodium chloride solution and dexamethasone for enema, but the experimental group used the aluminum phosphate gel for enema on the basis of the control group, and then the clinical＇ treatment effect was compared between the two groups. Results The research results showed that the total treatment effective rate in the experimental group was obviously higher than that in the control group[38（90.48%） vs 32（76.19%）], and the difference was statistically significant （P〈0.05）, after treatment, the DAI in the experimental group was obviously higher than that in the control group[（3.22±l.16）points vs （2.45±1.58）points], and the difference was statistically significant （P〈0.05）, and the im- provement time of bellyache, diarrhea, tenesmus and blood stool in the experimental group was obviously better than those in the control group [（3.4±0.3）,（3.8±0.6）,（3.6±0.6）,（5.3±0.6）d vs （3.6±0.5）,（4.0±0.7）,（5.8±0.3）,（8.6±0.7）d], and the difference was statistically significant（P〈O.05）. Conclusion The colon retention enema and enema fluid of alu- minum phosphate gel for patients with inflammatory bowel disease can improve the treatment effect of patients, shorten the rehabilitation time and obtain an obvious clinical effect, which is worth clinical nromotinn_