颗粒蛋白前体在呼吸系统疾病的研究进展

Role of PGRN in respiratory disease

颗粒蛋白前体．（PGRN）是多功能的生长因子，在正常组织的发生、增生、再生、宿主防御的动态调节中起重要作用。诸多研究表明PGRN参与传染病、伤口愈合、肿瘤发生、神经增殖和退化性疾病。目前研究发现PGRN在炎性疾病中发挥重要作用，此外，PGRN在COPD、ARDS、非小细胞肺癌、间质性肺病中也有研究，本文就PGRN在肺部疾病中的研究进展进行综述。

Progranulin （PGRN）, a multifunctional growth factor, plays an important role in the dynamics regulation of normal tissue development, proliferation, regeneration, and host-defense response. Therefore, it has been widely studied in the fields of infectious diseases, healing, tumorigenesis, and neuro proliferative and degenerative diseases. PGRN plays an important role in inflammatory disease. Besides, scientific researches of PGRN in chronic obstructive pulmonary disease, acute respiratory distress syndrome, non-small cell lung cancer, interstitial lung disease have been conducted. This review summarizes recent studies on the role of PGRN in the respiratory disease.